By: ART Fertility Program: Drs. Honea, Houserman, Long and
Allemand
PCOS is a common diagnosis among women, but one that can be
filled with misinformation and discouragement.
The ART Fertility Specialists help us understand PCOS, what it means to
a fertility diagnosis, and why there are plenty of reasons to be optimistic
about successful pregnancy after a PCOS diagnosis.
What is PCOS?
PCOS stands for polycystic ovary syndrome, which is a very
common condition. It involves
dysfunctional male hormone production by the ovaries. All females have male hormones to some
extent, but a patient with PCOS usually has a much higher level and it affects
her ovulation and ability to conceive. It occurs in anywhere from five to fifteen
percent of women, and is probably the most common single diagnosis seen in our
office.
How does one diagnose
PCOS in a patient?
Common symptoms of PCOS can include irregular or absent
menstrual cycles, acne, and excessive hair growth on chin, sideburns,
lower abdomen and around nipples. These
are symptoms that are easy to see. Once
we look a bit deeper, we’ll see multiple small follicles in the ovary (referred
to as antral count). An antral count of 12 or greater in one ovary is consistent
with PCOS. We’ll also run androgen blood
levels which are often elevated with PCOS.
If a woman has two out of those three criteria – multiple follicles on
the ultrasound, elevated male hormone levels, or irregular cycles – it’s likely
we’re dealing with PCOS.
What causes PCOS in
women?
We really don’t know the cause. There is some family history component, but
there isn’t any genetic test to determine how likely a woman is to develop
PCOS. Women with a family history do
have a higher chance of developing PCOS, but we have patients with no such
history. There are probably some
environmental effects as well. Some of
our patients had no symptoms and conceived their first child without any
treatment, then gained a significant amount of weight with their first child
and started showing symptoms of PCOS.
Most cases we see are weight-related, and often a weight gain can push
women over the edge of that hormonal balance and cause PCOS to show itself.
What is the next step
for a patient after PCOS has been diagnosed?
If it is PCOS, the basic decision is if this patient is
trying to achieve pregnancy. If she is,
we help her ovulate and release eggs more effectively than her body has been
previously. If the woman isn’t trying to
conceive, we focus on balancing out the hormone levels to help reduce her
symptoms.
What treatment
options are available for women with PCOS?
We spend time talking about what lifestyle management can do
to help with symptoms, especially weight management. Women with PCOS have a two to five time
greater risk for developing diabetes.
Weight gain exacerbates PCOS symptoms.
Even a five to ten percent weight loss can improve PCOS symptoms and
improve her response to fertility treatments.
We also encourage exercise, avoidance of excessive alcohol and no tobacco
use.
If the patient has never tried any fertility treatments, we
will try fertility pills such as Clomid or Letrazole. Clomid is the only FDA approved fertility
pill for treatment of ovulatory dysfunction.
However, it has many side effects including irritability, formation of
ovarian cysts, blurred vision, and adverse effect on cervical mucus and uterine
lining. For this reason we often use
Letrazole as our first line fertility pill because it has less side effects and
similar, if not better, pregnancy rates.
There is much acceptance of Letrazole use in the infertility
literature. We often combine ovulation
enhancing drugs with Glucophage to lower insulin resistance.
If fertility pills are not successful, we usually move to gonadotropin
therapy referred to as ovulation induction or super ovulation. Success rates are as high as 20-25% per
cycle, but multiple birth rate results are 20-25% twins, 5% triplets and a 2%
chance of quadruplets or greater. One
way to avoid triplets or greater is to move to in-vitro fertilization where we
can control how many embryos are transferred into the woman’s uterus. With in-vitro fertilization, there are now
ways to avoid ovarian hyperstimulation where ovaries swell to as much as 10 to 15
centimeters in size, much fluid weight is gained and often there are problems
with keeping liquids digested.
Hospitalization is then sometimes needed. The current thinking is for patients who have
severe PCOS to use IVF, trigger ovulation with Lupron, a GnRH agonist, retrieve
eggs and then freeze the embryos five days later at the blastocyst stage. So far no severe hyperstimulation has been
reported using this strategy. Thawing of
embryos at the blastocyst stage is now 90% successful and resulting pregnancy
rates in frozen embryo cycles are excellent.
What should women
with PCOS remember?
We really want to encourage women with PCOS. This is a very common diagnosis and it can be
frustrating to women because there is considerable misinformation in the public
domain about what PCOS is and what it is not.
Women with PCOS should be very encouraged about a future pregnancy. This is something we see every day in our
program and we have had great success in helping women conceive after a PCOS
diagnosis. There are many reasons to be
hopeful about pregnancy success after a PCOS diagnosis.